Selank
250–300 mcg · Daily
Robert
Founder, F*CK Getting Old — independent researcher, not a medical professional.
Last reviewed · 2 cited sources
Evidence
- Human Studies
- 8
- Animal Studies
- 30
- Clinical Status
- Off-label
- Confidence
- Low
- Long-Term Safety
- Established within Russian clinical use; limited independent replication elsewhere
What this score is: a measure of how much research exists and how far along it is (animal-only vs. human trials, research-stage vs. FDA approved) — not how safe, effective, or worth trying a compound is. A low score usually means “early stage” or “understudied,” not “bad.” A high score doesn’t mean “better” for your goals than a lower-scored one.
This is not my personal rating of the compound, not a recommendation, and not medical advice. It’s a general research synthesis for informational purposes only, not a live literature count. See the linked research and talk to a licensed clinician before making decisions based on it.
Mechanism
Selank is a synthetic analog of tuftsin, also developed in Russia, studied for anxiolytic effects potentially linked to GABA and serotonin system modulation and BDNF expression. Like Semax, it is used clinically in Russia but not FDA approved or widely replicated in Western trials.
Common Protocols
- 250–300 mcg daily, intranasal or subcutaneous
- Traditional use is intranasal
Side Effects
- Nasal irritation (intranasal route)
- Limited formal adverse-event data outside Russian trials
Interactions
- Limited formal interaction data; caution combining with other anxiolytic or sedating compounds
Practical Details
- Cost
- $
- Typical Vial Size
- 5 mg
- Storage
- Refrigerate after reconstitution
Key Studies & Reviews
- Medvedev VE et al. (2015). Optimization of the treatment of anxiety disorders with selank (in Russian). Zh Nevrol Psikhiatr Im S S Korsakova. PMID 26356395.
- Vyunova TV et al. (2018). Peptide-based anxiolytics: the molecular aspects of heptapeptide Selank biological activity. Protein Pept Lett. PMID 30255741.
Search the Research
Selank FAQ
What is the typical Selank dosage?
Commonly reported protocols: 250–300 mcg daily, intranasal or subcutaneous; Traditional use is intranasal. Our reference entry uses 250–300 mcg, Daily. These reflect protocols reported in research and user communities, not a medical recommendation — dosing should be decided with a clinician.
What are the side effects of Selank?
Reported side effects include: Nasal irritation (intranasal route); Limited formal adverse-event data outside Russian trials.
Is Selank FDA approved?
Selank is not FDA approved for the uses discussed here; it is used off-label or through compounding pharmacies, with less oversight of quality and dosing.
How much research is there on Selank?
Our evidence profile counts roughly 8 human and 30 animal studies, with low overall confidence. Long-term safety: Established within Russian clinical use; limited independent replication elsewhere.
Does Selank interact with other drugs or supplements?
Limited formal interaction data; caution combining with other anxiolytic or sedating compounds.
How do I reconstitute Selank?
A common setup is a 5 mg vial mixed with 2 mL of bacteriostatic water, which puts a 250–300 mcg dose at about 10 units on a U-100 insulin syringe. Use the reconstitution calculator with your own vial and dose to get exact numbers. Storage: Refrigerate after reconstitution.
Related compounds
Anxiolytic, cognitive enhancement