TB-500
2.5–5 mg · 2×/week loading, then weekly
Robert
Founder, F*CK Getting Old — independent researcher, not a medical professional.
Last reviewed · 3 cited sources
Evidence
- Human Studies
- 2
- Animal Studies
- 35
- Clinical Status
- Research
- Confidence
- Low
- Long-Term Safety
- Unknown — no controlled human safety data for the synthetic fragment specifically
What this score is: a measure of how much research exists and how far along it is (animal-only vs. human trials, research-stage vs. FDA approved) — not how safe, effective, or worth trying a compound is. A low score usually means “early stage” or “understudied,” not “bad.” A high score doesn’t mean “better” for your goals than a lower-scored one.
This is not my personal rating of the compound, not a recommendation, and not medical advice. It’s a general research synthesis for informational purposes only, not a live literature count. See the linked research and talk to a licensed clinician before making decisions based on it.
Mechanism
A synthetic fragment of thymosin beta-4, studied in animal models for actin regulation involved in cell migration and wound healing. Naturally occurring thymosin beta-4 has more human research behind it than this synthetic fragment specifically.
Common Protocols
- 2.5–5 mg 2x/week for a loading phase, then weekly maintenance, subcutaneous
Side Effects
- Injection site irritation
- No systematic human safety data
Interactions
- No formal interaction data exists
Practical Details
- Cost
- $$
- Typical Vial Size
- 10 mg
- Storage
- Refrigerate after reconstitution
Key Studies & Reviews
- Hannappel E (2007). beta-Thymosins. Ann N Y Acad Sci. PMID 17468232.
- Sosne G (2018). Thymosin beta 4 and the eye: the journey from bench to bedside. Expert Opin Biol Ther. PMID 30063853.
- Mendias CL, Awan TM (2026). Safety and efficacy of approved and unapproved peptide therapies for musculoskeletal injuries and athletic performance. Sports Med. PMID 41966639.
Search the Research
TB-500 FAQ
What is the typical TB-500 dosage?
Commonly reported protocols: 2.5–5 mg 2x/week for a loading phase, then weekly maintenance, subcutaneous. Our reference entry uses 2.5–5 mg, 2×/week loading, then weekly. These reflect protocols reported in research and user communities, not a medical recommendation — dosing should be decided with a clinician.
What are the side effects of TB-500?
Reported side effects include: Injection site irritation; No systematic human safety data.
Is TB-500 FDA approved?
TB-500 is not FDA approved for human use and is generally sold as a research chemical, so purity and dosing are not regulated.
How much research is there on TB-500?
Our evidence profile counts roughly 2 human and 35 animal studies, with low overall confidence. Long-term safety: Unknown — no controlled human safety data for the synthetic fragment specifically.
Does TB-500 interact with other drugs or supplements?
No formal interaction data exists.
How do I reconstitute TB-500?
A common setup is a 10 mg vial mixed with 2 mL of bacteriostatic water, which puts a 2.5–5 mg dose at about 50 units on a U-100 insulin syringe. Use the reconstitution calculator with your own vial and dose to get exact numbers. Storage: Refrigerate after reconstitution.
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