Sermorelin
200–300 mcg · Daily, PM
Robert
Founder, F*CK Getting Old — independent researcher, not a medical professional.
Last reviewed · 2 cited sources
Evidence
- Human Studies
- 20
- Animal Studies
- 15
- Clinical Status
- Off-label
- Confidence
- Moderate
- Long-Term Safety
- Established for the discontinued FDA-approved diagnostic product; long-term safety data for ongoing off-label anti-aging use is much thinner
What this score is: a measure of how much research exists and how far along it is (animal-only vs. human trials, research-stage vs. FDA approved) — not how safe, effective, or worth trying a compound is. A low score usually means “early stage” or “understudied,” not “bad.” A high score doesn’t mean “better” for your goals than a lower-scored one.
This is not my personal rating of the compound, not a recommendation, and not medical advice. It’s a general research synthesis for informational purposes only, not a live literature count. See the linked research and talk to a licensed clinician before making decisions based on it.
Mechanism
Sermorelin is a synthetic analogue of the first 29 amino acids of growth hormone-releasing hormone (GHRH), stimulating the pituitary to release its own GH in a pulsatile pattern. It was FDA-approved (as Geref) for diagnosing GH deficiency in children before being discontinued commercially; it is now available primarily through compounding pharmacies.
Common Protocols
- 200–300 mcg subcutaneous nightly, ideally on an empty stomach before bed to align with natural GH pulses
- Often used in cycles of several months with periodic breaks
Side Effects
- Injection site redness or itching
- Flushing or headache shortly after injection
- Rare: dizziness
Interactions
- Effects may be blunted by high blood sugar around the time of injection — avoid a large meal immediately before dosing
Practical Details
- Cost
- $$
- Typical Vial Size
- 5 mg
- Storage
- Refrigerate after reconstitution
Key Studies & Reviews
- Sinha DK et al. (2020). Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. PMID 32257855.
- Dominikowski A et al. (2026). The emerging landscape of performance-enhancing peptides modulating the GH-IGF1 axis. Front Endocrinol. PMID 42395176.
Search the Research
Sermorelin FAQ
What is the typical Sermorelin dosage?
Commonly reported protocols: 200–300 mcg subcutaneous nightly, ideally on an empty stomach before bed to align with natural GH pulses; Often used in cycles of several months with periodic breaks. Our reference entry uses 200–300 mcg, Daily, PM. These reflect protocols reported in research and user communities, not a medical recommendation — dosing should be decided with a clinician.
What are the side effects of Sermorelin?
Reported side effects include: Injection site redness or itching; Flushing or headache shortly after injection; Rare: dizziness.
Is Sermorelin FDA approved?
Sermorelin is not FDA approved for the uses discussed here; it is used off-label or through compounding pharmacies, with less oversight of quality and dosing.
How much research is there on Sermorelin?
Our evidence profile counts roughly 20 human and 15 animal studies, with moderate overall confidence. Long-term safety: Established for the discontinued FDA-approved diagnostic product; long-term safety data for ongoing off-label anti-aging use is much thinner.
Does Sermorelin interact with other drugs or supplements?
Effects may be blunted by high blood sugar around the time of injection — avoid a large meal immediately before dosing.
How do I reconstitute Sermorelin?
A common setup is a 5 mg vial mixed with 2 mL of bacteriostatic water, which puts a 200–300 mcg dose at about 12 units on a U-100 insulin syringe. Use the reconstitution calculator with your own vial and dose to get exact numbers. Storage: Refrigerate after reconstitution.
Related compounds
GHRH analogue; short half-life, inject before bed