Kisspeptin-10
100 mcg · As directed/research protocol
Robert
Founder, F*CK Getting Old — independent researcher, not a medical professional.
Last reviewed · 2 cited sources
Evidence
- Human Studies
- 20
- Animal Studies
- 40
- Clinical Status
- Research
- Confidence
- Low
- Long-Term Safety
- Studied mostly in short, monitored clinical research infusions; no long-term safety data for the self-administered subcutaneous use common in research-chemical circles
What this score is: a measure of how much research exists and how far along it is (animal-only vs. human trials, research-stage vs. FDA approved) — not how safe, effective, or worth trying a compound is. A low score usually means “early stage” or “understudied,” not “bad.” A high score doesn’t mean “better” for your goals than a lower-scored one.
This is not my personal rating of the compound, not a recommendation, and not medical advice. It’s a general research synthesis for informational purposes only, not a live literature count. See the linked research and talk to a licensed clinician before making decisions based on it.
Mechanism
Kisspeptin-10 is the active fragment of kisspeptin, a neuropeptide that sits upstream of GnRH and drives the entire hypothalamic-pituitary-gonadal axis. It has been used in clinical research settings (often via controlled IV infusion, not home subcutaneous injection) to study fertility and reproductive hormone regulation.
Common Protocols
- Human research has generally used controlled IV infusion protocols in clinical settings, not the self-directed subcutaneous dosing common with other research peptides — self-administered dosing is not well established
Side Effects
- Flushing
- Nausea reported in some infusion studies
- Effects on hormone levels are the whole point of the mechanism, which cuts both ways outside a monitored setting
Interactions
- Directly affects LH/FSH/testosterone or estrogen output — combining with other hormone-modulating compounds without monitoring is poorly understood
Practical Details
- Cost
- $$
- Typical Vial Size
- 5 mg
- Storage
- Refrigerate after reconstitution
Key Studies & Reviews
- Yeung AC et al. (2026). Chronic subcutaneous kisspeptin-10 stimulates gonadotropin secretion for 12 days in healthy men. Eur J Endocrinol. PMID 42549827.
- George JT et al. (2013). Kisspeptin-10 stimulates serum testosterone and LH secretion in men with type 2 diabetes and mild biochemical hypogonadism. Clin Endocrinol. PMID 23153270.
Search the Research
Kisspeptin-10 FAQ
What is the typical Kisspeptin-10 dosage?
Commonly reported protocols: Human research has generally used controlled IV infusion protocols in clinical settings, not the self-directed subcutaneous dosing common with other research peptides — self-administered dosing is not well established. Our reference entry uses 100 mcg, As directed/research protocol. These reflect protocols reported in research and user communities, not a medical recommendation — dosing should be decided with a clinician.
What are the side effects of Kisspeptin-10?
Reported side effects include: Flushing; Nausea reported in some infusion studies; Effects on hormone levels are the whole point of the mechanism, which cuts both ways outside a monitored setting.
Is Kisspeptin-10 FDA approved?
Kisspeptin-10 is not FDA approved for human use and is generally sold as a research chemical, so purity and dosing are not regulated.
How much research is there on Kisspeptin-10?
Our evidence profile counts roughly 20 human and 40 animal studies, with low overall confidence. Long-term safety: Studied mostly in short, monitored clinical research infusions; no long-term safety data for the self-administered subcutaneous use common in research-chemical circles.
Does Kisspeptin-10 interact with other drugs or supplements?
Directly affects LH/FSH/testosterone or estrogen output — combining with other hormone-modulating compounds without monitoring is poorly understood.
How do I reconstitute Kisspeptin-10?
A common setup is a 5 mg vial mixed with 2 mL of bacteriostatic water, which puts a 100 mcg dose at about 2 units on a U-100 insulin syringe. Use the reconstitution calculator with your own vial and dose to get exact numbers. Storage: Refrigerate after reconstitution.
Related compounds
Upstream regulator of the reproductive hormone axis; mostly a research tool