Epithalon
5–10 mg · Daily for 10-day cycle
Robert
Founder, F*CK Getting Old — independent researcher, not a medical professional.
Last reviewed · 2 cited sources
Evidence
- Human Studies
- 5
- Animal Studies
- 30
- Clinical Status
- Research
- Confidence
- Low
- Long-Term Safety
- Unknown outside a narrow set of Russian institutional studies
What this score is: a measure of how much research exists and how far along it is (animal-only vs. human trials, research-stage vs. FDA approved) — not how safe, effective, or worth trying a compound is. A low score usually means “early stage” or “understudied,” not “bad.” A high score doesn’t mean “better” for your goals than a lower-scored one.
This is not my personal rating of the compound, not a recommendation, and not medical advice. It’s a general research synthesis for informational purposes only, not a live literature count. See the linked research and talk to a licensed clinician before making decisions based on it.
Mechanism
A synthetic tetrapeptide studied primarily by a small number of affiliated Russian research groups (Khavinson et al.) for potential telomerase activation and pineal gland regulation. The "anti-aging" literature has not been independently replicated at scale outside those institutions.
Common Protocols
- 5–10 mg daily for a 10–20 day cycle, subcutaneous, per the Russian research protocols this is based on; typically limited to 1–2 cycles per year in that literature
Side Effects
- Injection site irritation
- No systematic independent safety data
Interactions
- No formal interaction data exists
Practical Details
- Cost
- $$
- Typical Vial Size
- 10 mg
- Storage
- Refrigerate after reconstitution
Key Studies & Reviews
- Araj SK et al. (2025). Overview of Epitalon — highly bioactive pineal tetrapeptide with promising properties. Int J Mol Sci. PMID 40141333.
- Khavinson VKh (2002). Peptides and ageing. Neuro Endocrinol Lett. PMID 12374906.
Search the Research
Epithalon FAQ
What is the typical Epithalon dosage?
Commonly reported protocols: 5–10 mg daily for a 10–20 day cycle, subcutaneous, per the Russian research protocols this is based on; typically limited to 1–2 cycles per year in that literature. Our reference entry uses 5–10 mg, Daily for 10-day cycle. These reflect protocols reported in research and user communities, not a medical recommendation — dosing should be decided with a clinician.
What are the side effects of Epithalon?
Reported side effects include: Injection site irritation; No systematic independent safety data.
Is Epithalon FDA approved?
Epithalon is not FDA approved for human use and is generally sold as a research chemical, so purity and dosing are not regulated.
How much research is there on Epithalon?
Our evidence profile counts roughly 5 human and 30 animal studies, with low overall confidence. Long-term safety: Unknown outside a narrow set of Russian institutional studies.
Does Epithalon interact with other drugs or supplements?
No formal interaction data exists.
How do I reconstitute Epithalon?
A common setup is a 10 mg vial mixed with 2 mL of bacteriostatic water, which puts a 5–10 mg dose at about 50 units on a U-100 insulin syringe. Use the reconstitution calculator with your own vial and dose to get exact numbers. Storage: Refrigerate after reconstitution.
Related compounds
Telomere elongation, anti-aging